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Organisms and Their Evolution
A book by
Stephen L. Talbott

Organisms and Their Evolution
Agency and Meaning in the Drama of Life

This is a complete draft of an online book freely available, with proper attribution, for noncommercial, personal use (including classroom use). The above title is presumably the final title for the book, which previously bore the temporary title, “Evolution As It Was Meant To Be — and the Living Narratives That Tell Its Story”. This material is part of the Biology Worthy of Life project of The Nature Institute. Copyright 2024 by Stephen L. Talbott. All rights reserved. Date of the current draft: December, 2024.

Table of Contents

An expanded Table of Contents follows below this chapter-level table

Preface

Part 1: The Life of Organisms

Chapter 1: The Keys to This Book

Chapter 2: The Organism’s Story

Chapter 3: What Brings Our Genome Alive?

Chapter 4: The Sensitive, Dynamic Cell

Chapter 5: Our Bodies Are Formed Streams

Chapter 6: Context: Dare We Call It Holism?

Chapter 7: Epigenetics: A Brief Introduction

Chapter 8: The Mystery of an Unexpected Coherence

Chapter 9: A Mess of Causes

Chapter 10: What Is the Problem of Form?

Chapter 11: Why We Cannot Explain the Form of Organisms

Chapter 12: Is a Qualitative Biology Possible?

Chapter 13: All Science Must Be Rooted in Experience

Technical Supplement to Part 1

Chapter 14: How Our Genes Come to Expression (It Takes an Epigenetic Village)

Chapter 15: Puzzles of the Microworld

Part 2: Extending the Organism’s Story:
Toward an Evolutionary Narrative

Chapter 16: Let’s Not Begin With Natural Selection

Chapter 17: Evolution Writ Small

Chapter 18: Teleology and Evolution

Chapter 19: Development Writ Large

Chapter 20: Inheritance and the Whole Organism

Chapter 21: Inheritance, Genetics, and the Particulate View of Life

Chapter 22: A Curiously Absolute Demand for Stable Variation

Chapter 23: The Evolution of Consciousness

Part 3: Beyond Biology

Chapter 24: Is the Inanimate World an Interior Reality?

POSTSCRIPTS

These Postscripts (and perhaps others still to come) are not part of the book itself, but will be made available online as they are written. Links are given below. Future links, if any, will be included in the list given here: https://bwo.life/bk/index.htm#postscripts


Expanded Table of Contents

Preface

Part 1: The Life of Organisms

Chapter 1: The Keys to This Book

Box 1.1: The Enigmatic Wisdom of the Potter Wasp

Theme #1: Narrative

Theme #2: Interiority

Theme #3: Holism

Theme #4: Blindsight

Some definitional hints about key biological terms

Agency

Archetype

Atoms/Molecules

Consciousness

Directive

Integral unity of the organism

Intention/intentional

Material

Material/physical/materialist/materialistic

Meaning

Purpose/purposeful/purposive

Telos-realizing

Where is the evidence? Two concluding notes

Chapter 2: The Organism’s Story

Introduction

Organisms are agents capable of expressing their own meanings

The end is more constant than the means of attaining it

Every organism is narrating a meaningful life story

Box 2.1: The Nesting Cycle of the Chaffinch

Where are we now?

Chapter 3: What Brings Our Genome Alive?

Introduction

The genome as you have probably not heard about it

Box 3.1: Some Standard Terminology

Of dynamism and mystery in the cell nucleus

Does the lawfulness of molecular interactions explain global coherence?

Where are we now?

Chapter 4: The Sensitive, Dynamic Cell

Introduction

Does the cell possess its own “senses” and “limbs”?

The sensitive “skin” and organelles of the cell

From information to life

Where are we now?

Chapter 5: Our Bodies Are Formed Streams

Introduction

A long way from crystalline order

The unexpected phases of life

Well-structured droplets

Box 5.1: On Shape-Shifting Blobs

How do you regulate flow and phases?

And then there is water — the mediator of flow

Where are we now?

Chapter 6: Context: Dare We Call It Holism?

Introduction

Which comes first, the cell or its niche?

‘More than the sum of its parts’: clarifying a cliché

Every biological context is a a complex of embodied ideas

Box 6.1: Some Call It Holism

Contextual wholes and living narratives

Where are we now?

Chapter 7: Epigenetics: A Brief Introduction

Introduction

An old problem newly recognized

Epigenetics — a useful term?

Unexpected discoveries

Grasping at epigenetic straws — is it really necessary?

Where are we now?

Chapter 8: The Mystery of an Unexpected Coherence

Introduction

Flexibility and precision in RNA splicing

The spliceosome

And further: everything could go backward

Can DNA coordinate splicing activity?

Shattering the Genome

Who’s on first — genes or proteins (or neither)?

A sense of the whole

Is an unexpected coherence the problem or the solution?

Where are we now?

Chapter 9: A Mess of Causes

Introduction

The seductive appeal of master controllers

More than an innocent abuse of language

Biological clocks: who is keeping time?

A well-studied worm

Of crosstalk, horror graphs, and collaboration

Box 9.1: Cause — Or Effect? Ambiguities related to gene expression

The problem of causation is fundamental to biology

Where are we now?

Chapter 10: What Is the Problem of Form?

Introduction

The problem of form exists even at the molecular level

Box 10.1: The Miracle of Wound Healing

Michael Levin: Revolutionary

Box 10.2: Electricity in the Developing Tadpole

Whole-part, future-oriented causation

Michael Levin: Counter-revolutionary

In what sense are machines end-directed?

A deep issue, unaddressed

An unquestioned model

Where are we now?

Chapter 11: Why We Cannot Explain the Form of Organisms

Introduction

Looking for physical explanations of form

The mastery of genetic switches

Can we trace form to something other than earlier form?

Endless transformations most beautiful

Where are we now?

Chapter 12: Is a Qualitative Biology Possible?

Introduction

An animal expressing the character of the tropical forest

The problem of organic form

How to generalize upon a transformational series

The movement is continuous and ideal

The formative movement requires both difference and sameness

An awareness of the movement changes our perception of the leaves

The movement manifests itself through the particulars

The question of causality

Each individual leaf is “coming from” and “passing to”

Whatever specifies the appearance of forms in time has causal significance

A clarification of dynamic form as cause

Threefoldness, the biology of form, and evolution

A starting point: living polarity in the human being

Interpenetration of the three aspects

Threefold organization in mammals

Subtle interweaving

Can evolutionists escape responsibility for explaining these patterns?

Where are we now?

Chapter 13: All Science Must Be Rooted in Experience

Introduction

Two distinguishable but indivisible aspects of human experience

Without relations of thought, we have only chaos

We do not see with our eyes alone

How do things around us become what they are?

Do we really want an empirical science?

It is careless thought that deceives us, not our senses

Earth and sun

The atom and beyond

Our “missing” bat sense

Closing thoughts

Technical Supplement to Part 1

Chapter 14: How Our Genes Come to Expression

Introduction

High expectations: the promise of molecular biology

Complications

Transcription factors and DNA engage in a complex play of form

Genes and proteins interact in tangled causal webs

The cell holds DNA in an intimate and instructive embrace

Getting started is hard to do

Carrying on

Table 14.1: Some factors regulating RNA polymerase elongation

Shaping a significant end

From genetics to epigenetics

MicroRNAs: a large world of tiny regulatory factors

DNA methylation

The nucleosome: a complex marriage of DNA and protein

A tale of tails

A still closer look

Movement and rhythm

Box 14.1: From Static Mechanism to Dynamic Regulator

A story mostly untold

Concluding thoughts

Where are we now?

Chapter 15: Puzzles of the Microworld

Introduction

This is not your familiar Aesop

From here to there — or, down the rabbit hole?

From wine to jelly

Viscous drag

Brownian movement

Chemical energies

Electrical forces

Polymerization

A world hard to get a grip on

What then?

Where are we now?

Part 2: Extending the Organism’s Story:
Toward an Evolutionary Narrative

Chapter 16: Let’s Not Begin With Natural Selection

Introduction

What are the “guaranteed results” of natural selection?

Wholeness, unity, type: how not to over-estimate genes

Unanswered questions

The “algorithm” of natural selection is widely treated as if it were an agent

The inadequacy of the theory of natural selection has long been noticed

Misplaced agency

Where are we now?

Chapter 17: Evolution Writ Small

Introduction

A ‘magical’ power of self-transformation

Box 17.1: Metamorphosis of an Insect

Metamorphosis of cells

Organisms manage their own germlines expertly

Where are we now?

Chapter 18: Teleology and Evolution

Introduction: “The life and death of cells”

Are there reasons to reject agency and teleology in evolution?

Individuals versus evolving populations

Do populations lack the necessary causal connections?

Can the presence and nature of agency be explained?

Is the claim of agency anthropomorphic?

What about the differences between development and evolution?

Natural selection: The shortest path to confusion is circular

(1) The problem of the “arrival of the fittest” remains

(2) The explanation assumes what it is supposed to explain

(3) There are no stable, tinkerable mechanisms

An aversion to meaning

Where are we now?

Chapter 19: Development Writ Large

Introduction

Evolution as a transformation of developmental processes

The heart of the evolving horse

Challenges of the heart

Evolutionists should not forget the directedness of biological activity

A thought experiment

Experiment concluded?

It is, in the primary sense, populations that evolve, not individual organisms

Far from a simple, linear process

A sprawling narrative

Where are we now?

Chapter 20: Inheritance and the Whole Organism

Introduction

E. S. Russell picked up Johannsen’s problem

Whole versus part

Material stuff — or activity?

Is it really all that difficult to recognize the principle of holism?

How independent are an organism’s traits?

Holism and the independence and integration of parts

Holism and natural selection

Where are we now?

Chapter 21: Inheritance, Genetics, and the Particulate View of Life

Introduction

DNA as the essential substance of evolution

The aggressive claims of population geneticists

Who defines what counts as an evolutionary process?

Getting to the bottom of things?

How the image of “particles” has distorted the biologist’s imagination

Facing up to the gestural reality of DNA

To view from the bottom or view from the top?

Where are we now?

Chapter 22: A Curiously Absolute Demand for Stable Variation

Introduction

Richard Dawkins, genes and the biologist’s “ultimate particles”

Development versus evolution

A short critique of Dawkins’ view

“Immortal” genetic variation

The embodied organism is not like a cloud

A counter-picture to the gene’s-eye view of evolution

Where are we now?

Chapter 23: The Evolution of Consciousness

Introduction

There was a primordial unity of inner and outer meaning

What words can teach us about the evolution of consciousness

Europeans and their changing landscape

History of ideas — or an evolution of consciousness

The long historical arc of the evolution of consciousness

An ideal degree of detachment — before and after

From myth to literacy: the coming into focus of the human individual

At the edge of literacy and beyond

The evolution of consciousness, like all evolution, is not a straight line

Where are we now?

Part 3: Beyond Biology

Chapter 24: Is the Inanimate World an Interior Reality?

Introduction

How the world lends itself to our knowing

We know the world through thinking as well as sensing

The interior dimension

The Cartesian diversion — is there a way to bypass it?

Can we recover the unity of the world?

Our eyes do not give us a representation of the world

We cognize the world by participating in its creation

The world as a form of speech

But what about the billions of galaxies?

Where are we now?

This document: https://bwo.life/bk/index0.htm

Steve Talbott :: Organisms and Their Evolution
Agency and Meaning in the Drama of Life